Let's look at the movies.
The first one is great...but the second one is just okay and...to hell with Lewis and Janine!
And if we're counting the 2016 movie...no contest. Cartoon wins.
The cartoon had some flaws, but I can't really think of any episode that stands out that I hate. I didn't even mind the Slimer cartoons because, hey I knew it wasn't canon, and it was fun.
Also, the cartoon really fleshed out the characters because they had years and years. And hey, a good chunk of the cartoon bad guys are better than the movie villains. Hell, the Stay Puff Marshmellow man of the toon is cooler than the movie version. I just like the idea he's just a nice guy who's just chilling in the chamber.
...And I'll admit it, as a kid I hated Janine's original voice and was happy when it was changed. Also her glasses were stupid.