Not really a Cabinet position, but South Carolina's Governor Nikki Haley was confirmed as UN Ambassador. This means that Lieutenant Governor Henry McMaster is now governor of SC.
Here's the funny part.
In SC, the legislature has a lot more power than the governor, to the point that the leaders of the House and Senate are often considered the most influential people in the state, not the governor.
The new governor McMaster will have to make the Senate's President Pro Tempore the new lieutenant governor. That's what the state constitution says, and the state Supreme Court has recently confirmed that. It's not a choice, the PPT must become the new lieutenant governor. But the PPT, Senator Hugh Leatherman, doesn't want to give up his powerful position for the chair-filling job of lieutenant governor.
So before McMaster was sworn in, Leatherman resigned his position as PPT. Sometime soon the Senate will elect a new PPT, who will then immediately become the new lieutenant governor, and then they'll elect another new PPT to actually keep the job, in all likelihood Leatherman again.